Persian physicians catalogued plant drugs for centuries; modern trials support some uses, not others, and have exposed real hazards
The Persian medical tradition as scholarship: who wrote what, when, and how it was received; then how a historical description becomes a testable hypothesis.
Academy fundamentals: Course 1, History of botanical medicine
Scope. History and evidence only: heritage is not evidence of efficacy or safety, and it is not a supply plan. U.S. sanctions (31 CFR 560.201) prohibit importing Iranian-origin goods without OFAC authorization; see Legal status.
The founder is of Persian heritage, and the company cites that tradition only through published scholarship
Explanation, details and sources
Dr. Amir H. Mehrkesh, EUTECNIQ's founder, is of Persian heritage. Founder-stated, October 22, 2026 This page describes the medical tradition associated with that heritage as it appears in published history of medicine. It is offered as context only; it is neither a credential nor evidence for any ingredient or product. His professional record is on the Founder page.
From the Sasanian period to the eighteenth century, Persian authors wrote some of the most widely read medical texts of their time
Dates follow the cited scholarship; where sources disagree, both dates are given. Names are transliterated as the cited authors write them.
Text version of the timeline, with sources for each entry
- c. 256–260 CE
Gondēšāpur
The Sasanian king Šāpur I founded the city of Gondēšāpur in southwestern Persia, probably between about 256 and 260. Later Arabic sources describe a hospital and medical school there; the hospital is first specifically mentioned for the year 765, in a thirteenth-century source, and Encyclopaedia Iranica treats the traditional account of the school with caution. Some medical-history reviews call it the world's first university; the documentary and archaeological record does not settle that claim.
Richter-Bernburg L. Gondēšāpur ii. History and medical school. Encyclopaedia Iranica, 2002 (updated 2018); Shoja MM, Tubbs RS. J Anat 2007;210:359–378; Daneshfard B, et al. J Family Med Prim Care 2022;11:4267–4272.
- c. 854/865–925
al-Rāzī (Rhazes)
Wrote al-Ḥāwī fī al-ṭibb (Latin Liber Continens), described as a 23-volume textbook used in European curricula into the fourteenth century, and the Liber ad Almansorem. Andreas Vesalius's first publication was a paraphrase of its ninth book. Birth years differ between sources: 865 in two reviews, 854 in a third.
Edriss H, et al. Am J Med Sci 2017;354:223–229; Compier AH. Med Hist 2012;56:3–25; Shoja MM, Tubbs RS. J Anat 2007.
- c. 980–1037
Ibn Sīnā (Avicenna) and the Canon of Medicine
Born about 980 near Bukhara and died in 1037 in Hamadan. He began the Canon (al-Qānūn fī al-ṭibb) about 1012 and completed it in Hamadan. It has five books; Book II covers simple drugs, arranged alphabetically after an essay on their general properties. The Canon also sets out seven rules for judging the effects of a drug.
Nasser M, Tibi A, Savage-Smith E. Ibn Sina's Canon of Medicine: 11th century rules for assessing the effects of drugs. J R Soc Med 2009;102:78–80 (James Lind Library).
- c. 1112
Jorjānī and the Treasure of the Khwarazm Shah
Esmāʿil Jorjānī (1042–1137) wrote the Zakhīre-ye Khwārazmshāhī in about 1112. It is considered the oldest medical encyclopedia written in Persian.
Shoja MM, et al. Neurosurgery 2007;61:1325–1330; Moattar F, et al. Iran Red Crescent Med J 2013;15:763–766.
- 12th century
Latin transmission
Gerard of Cremona (1114–1187) translated the Canon into Latin in Toledo. He also translated Ibn Sīnā's medical poem, which circulated with the Latin Canon and in the Articella, a collection used in the universities of Salerno, Montpellier, Bologna and Paris up to the seventeenth century. An Arabic edition of the Canon was printed in Rome in 1593.
Arráez-Aybar LA, et al. Ann Anat 2015;198:21–33; Abdel-Halim RE. Urol Ann 2014;6:1–12; Nasser M, et al. 2009.
- 18th century
ʿAqīlī Shīrāzī and the Makhzan al-Adwiya
Hakim ʿAqīlī Shīrāzī wrote the Makhzan al-Adwiya, a Persian materia medica of single (simple) drugs that modern researchers still read alongside the Canon.
Mosaffa-Jahromi M. Iran J Med Sci 2016;41(3 Suppl):S50; Parsa E, et al. Curr Drug Discov Technol 2019;16:400–405.
A historical description is a hypothesis, and it has to survive identity, dose and safety checks before a trial can test it
The proposed sequence for using historical sources Management proposal. Agreement between an old text and a modern laboratory assay only justifies a test.
Text version of the six steps
- Read in contextUse a scholarly edition or translation and record which text, book and entry is cited.
- Fix the identityHistorical names map uncertainly to species. Assign a POWO accepted name and plant part, as in the atlas.
- Record the preparationPart, processing and dose described in the text, compared with modern products.
- Screen safety firstSearch case reports, LiverTox and toxicology data before any human exposure.
- State the hypothesisOne measurable outcome in a defined population.
- Test properlyRandomized, controlled and adequately powered; see Clinical research.
Text version: what the historical sources record and what modern evidence shows, with sources
| Botanical | What the historical sources record, as modern reviews report it | What modern human or toxicological evidence shows | Evidence |
|---|---|---|---|
| Saffron Crocus sativus | Ibn Sīnā describes saffron in Book II of the Canon, including antidepressant, hypnotic and anti-inflammatory uses; al-Rāzī's al-Ḥāwī lists similar properties. Hosseinzadeh H, Nassiri-Asl M. Phytother Res 2013;27:475–483; Mollazadeh H, et al. Iran J Basic Med Sci 2015;18:1153–1166. | A GRADE-rated meta-analysis of 34 RCTs (1,769 participants) found lower self-rated depression (BDI −4.39) and anxiety (BAI −5.06) scores, but no effect on clinician-rated scales. A 6-week RCT in 51 healthy adults with subclinical symptoms found no effect on its primary outcome. Mahmoudi R, et al. Nutr Neurosci 2026;29:816–837; Amadieu C, et al. Am J Clin Nutr 2025;122:1625–1635. | Mixed: self-rated benefit, clinician-rated null |
| Black seed Nigella sativa | A review reports that Ibn Sīnā refers to black seed in the Canon as a seed that stimulates the body's energy. Ahmad A, et al. Asian Pac J Trop Biomed 2013;3:337–352. | A meta-analysis of RCTs found systolic blood pressure 3.06 mmHg and diastolic 2.69 mmHg lower than control, with very high heterogeneity between trials. Kavyani Z, et al. Phytother Res 2023;37:3224–3238. | Small effect, inconsistent trials |
| Zarāvand Aristolochia rotunda | Described in 2023 as "a commonly used drug in Iran's traditional medicine and pharmacy" for respiratory complaints, back pain, headache and wounds. Abolhassanzadeh Z, et al. Heliyon 2023;9:e21848. | High doses damaged rat kidneys in that study. Aristolochic acids are listed by the U.S. National Toxicology Program as "known to be human carcinogens", first listed in 2011; the evidence was first identified in Belgian patients with kidney disease who had taken herbal products contaminated with Aristolochia, and FDA issued warnings on botanical products containing aristolochic acid in 2000 and 2001. Abolhassanzadeh Z, et al. 2023; National Toxicology Program, Report on Carcinogens, 15th ed., Aristolochic Acids. | Animal Documented safety concern |
- Safranal, C10H14O (PubChem CID 61041): the major volatile component of saffron, responsible for its aroma.
- Crocetin, C20H24O4 (CID 5281232): a carotenoid dicarboxylic acid found in the crocus flower.
- Thymoquinone, C10H12O2 (CID 10281): a compound isolated from Nigella sativa.
- Aristolochic acid I, C17H11NO7 (CID 2236): the most abundant of the aristolochic acids, which NTP lists as known human carcinogens.
Data table and search terms
| Botanical | 2000 | 2005 | 2010 | 2015 | 2020 | 2025 | Search terms |
|---|---|---|---|---|---|---|---|
| Saffron | 18 | 34 | 67 | 141 | 242 | 311 | (saffron OR "Crocus sativus" OR crocin) |
| Black seed | 12 | 41 | 85 | 142 | 248 | 344 | ("Nigella sativa" OR "black seed" OR "black cumin" OR thymoquinone) |
| Aristolochia and aristolochic acids | 39 | 51 | 71 | 94 | 108 | 94 | (Aristolochia OR "aristolochic acid" OR "aristolochic acids") |
- Agreement between a text and an assay≠clinical efficacy
- Centuries of use≠demonstrated safety
- A historical plant name≠a verified species
Academy: organ toxicity of botanicals, including aristolochic acid (Course 9) · Persia among the world's traditions (Course 1)
Respecting the tradition means citing it accurately, honoring access and benefit-sharing law, and keeping sanctions out of the supply chain
Text version of the three obligations, with sources
Access and benefit-sharing
The Nagoya Protocol on access and benefit-sharing has 143 Parties. The United States is not a Party to it, nor to the Convention on Biological Diversity, which it signed on June 4, 1993. Provider countries' own access laws can still apply to research on material collected there, so EUTECNIQ would ask counsel before any such work. Management proposal
CBD Secretariat, list of Parties (accessed October 22, 2026).
Attribution
Historical knowledge would be cited to its texts, editions and translators. A traditional preparation would not be presented as an EUTECNIQ invention, and any claim drawn from a text would be labeled as traditional use, not as clinical evidence. Management proposal
Sanctions
U.S. sanctions (31 CFR 560.201) prohibit importing goods of Iranian origin unless OFAC authorizes it; the general authorization for Iranian foodstuffs ended on August 6, 2018. The same section excludes "information and informational materials" from the prohibition, so scholarship is treated differently from goods. Whether processing in another country changes origin is a question for sanctions counsel. This is not legal advice.
31 CFR 560.201; 83 FR 30335 (June 28, 2018). See Legal status.
Explanation, details and sources: sanctions
U.S. sanctions (31 CFR 560.201) prohibit importing goods of Iranian origin unless OFAC authorizes it; the general authorization for Iranian foodstuffs ended on August 6, 2018. Whether processing in another country changes origin is a question for sanctions counsel. See Legal status.
See how regional botanicals compare today
The botanical atlas sets 34 regional botanicals side by side, with evidence, safety, CITES and customs status for each.